Journal
NEUROSCIENCE LETTERS
Volume 363, Issue 2, Pages 178-181Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2004.04.004
Keywords
sex difference; aging; N-methyl-D-aspartate (NMDA); pain; antinociception; kappa
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Funding
- NIDA NIH HHS [DA15191] Funding Source: Medline
- NIDCR NIH HHS [DE12735] Funding Source: Medline
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The effects of aging on sex differences in analgesia from the kappa-opioid agonist, U50,488H (U50), were examined in C57BL/6J mice. U50 analgesia can be blocked by the N-methyl-D-aspartate receptor antagonist, MK-801 (MK), in male rodents and gonadectomized females, but not hormonally intact or estrogen-replaced fern ales, Suggesting the existence of alternate neurochemical mediation in females. We now report that MK antagonism of U50 analgesia is age-dependent in females. That is, reproductively senescent females display MK-sensitive U50 analgesia qualitatively similar to that displayed by males or hormonally deprived young females. Age-related reductions in U50 analgesic magnitude were also observed in females. Thus, age and gender are likely to alter the clinical efficacy of analgesic drugs active at kappa-opioid receptors. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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