4.8 Article

Palladium-catalyzed decarboxylation and decarbonylation under hydrothermal conditions: Decarboxylative deuteration

Journal

ORGANIC LETTERS
Volume 6, Issue 12, Pages 2071-2073

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol0492602

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Decarboxylation of free carboxylic acid was performed by Pd/C catalyst under hydrothermal water (250 degreesC/4 MPa). Under the hydrothermal conditions of deuterium oxide, decarbonylative deuteration was observed to give fully deuterated hydrocarbons from carboxylic acids or aldehydes.

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