Journal
ORGANIC LETTERS
Volume 6, Issue 12, Pages 1951-1954Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol049503q
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- NCI NIH HHS [R01 CA 47135] Funding Source: Medline
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Bioassay-guided fractionation of the sponge Psammocinia sp. afforded psymberin (1) possessing 5S,8S,9S,11R,13R,15S,16R,17R stereochemistry. Psymberin exhibits structural similarities to the pederin family metabolites. The potent cytotoxicty and unique structural features of 1 make it a promising lead for therapeutic development.
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