Journal
SCIENCE
Volume 304, Issue 5677, Pages 1675-1678Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1098096
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- NICHD NIH HHS [HD29446] Funding Source: Medline
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During embryogenesis, differentiation of skeletal muscle is regulated by transcription factors that include members of the Msx homeoprotein family. By investigating Msx1 function in repression of myogenic gene expression, we identified a physical interaction between Msx1 and H1b, a specific isoform of mouse histone H1. We found that Msx1 and H1b bind to a key regulatory element of MyoD, a central regulator of skeletal muscle differentiation, where they induce repressed chromatin. Moreover, Msx1 and H1b cooperate to inhibit muscle differentiation in cell culture and in Xenopus animal caps. Our findings define a previously unknown function for linker histones in gene-specific transcriptional regulation.
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