4.4 Article

Efficient one-pot synthesis of anti-HIV and anti-tumour β-carbolines

Journal

TETRAHEDRON
Volume 60, Issue 25, Pages 5315-5318

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2004.04.079

Keywords

harman; harmine; beta-carboline; electrocyclisation; 1-aryl-beta-carboline

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Thermal electrocyclisation of the azahexatriene system has been used as a key step for the synthesis of anti-HIV and anti-tumour compounds, harman, derivatives of harman and 1-aryl-beta-carbolines. A one-pot reaction sequence was used to furnish these compounds in good yield. (C) 2004 Elsevier Ltd. All rights reserved.

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