Journal
JOURNAL OF COMPARATIVE NEUROLOGY
Volume 474, Issue 1, Pages 136-148Publisher
WILEY
DOI: 10.1002/cne.20120
Keywords
olfactory epithelium; olfactory bulb; cell death
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Funding
- NIDCD NIH HHS [5 R01 DC04579-03] Funding Source: Medline
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Neuronal apoptosis is a key component in the sculpting of tissues during embryonic and postnatal development and is driven largely by the action of caspases. In the mouse olfactory system, caspase-3 and -9 are expressed in olfactory receptor neurons (ORNs) of adult mice, and their selective retrograde activation drives ORN apoptosis following ablation of their target, the olfactory bulb (013). Here, we show that both of these caspases are expressed at the earliest stages of ORN embryonic development, and their expression is concentrated in outgrowing ORN axons. The retention, in null mice for both caspases, of a population of ORNs that would normally undergo developmental apoptosis beginning at E13 of development, results in a permanently expanded population of ORNs. In turn, in some caspase-3 null mice, the ORN target organ, the OB, also develops abnormally, resulting in the formation of secondary, apparently functional, extracranial ectopic OBs. (C) 2004 Wiley-Liss, Inc.
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