Journal
BLOOD
Volume 103, Issue 12, Pages 4672-4673Publisher
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2003-11-4060
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Funding
- NIDDK NIH HHS [DK 58086, DK 61763, DK 30534] Funding Source: Medline
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Mutations that lead to a loss of the copper-containing plasma enzyme ceruloplasmin disrupt mammalian iron homeostasis. The mechanism by which ceruloplasmin mobilizes iron from cell stores has been controversial. We demonstrate that injection of a soluble copper-containing yeast protein Fet3p can restore iron homeostasis in phlebotomized mice with a deletion of the ceruloplasmin gene. These results show the conservation of function of copper-containing proteins in eukaryotic iron metabolism. (C) 2004 by The American Society of Hematology.
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