Journal
GENES & DEVELOPMENT
Volume 18, Issue 12, Pages 1371-1384Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1209304
Keywords
nuclear structure; genomic organization; transcription; expression neighborhood; genetic networks
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Funding
- NHLBI NIH HHS [HL57620] Funding Source: Medline
- NIDDK NIH HHS [DK44746] Funding Source: Medline
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The extent to which the nucleus is functionally organized has broad biological implications. Evidence supports the idea that basic nuclear functions, such as transcription, are structurally integrated within the nucleus. Moreover, recent studies indicate that the linear arrangement of genes within eukaryotic genomes is nonrandom. We suggest that determining the relationship between nuclear organization and the linear arrangement of genes will lead to a greater understanding of how transcriptomes, dedicated to a particular cellular function or fate, are coordinately regulated. Current network theories may provide a useful framework for modeling the inherent complexity the functional organization of the nucleus.
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