Journal
JOURNAL OF NEUROSCIENCE METHODS
Volume 136, Issue 1, Pages 1-21Publisher
ELSEVIER
DOI: 10.1016/j.jneumeth.2004.02.025
Keywords
optical imaging; intrinsic signals; event-related; Fourier analysis; functional architecture; development; plasticity
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Since optical imaging (OI) of intrinsic signals was first developed in the 1980s, significant advances have been made regarding our understanding of the origins of the recorded signals. The technique has been refined and the range of its applications has been broadened considerably. Here we review recent developments in methodology and data analysis as well as the latest findings on how intrinsic signals are related to metabolic cost and electrophysiological activity in the brain. We give an overview of what optical imaging has contributed to our knowledge of the functional architecture of sensory cortices, their development and plasticity. Finally, we discuss the utility of OI for functional studies of the human brain as well as in animal models of neuropathology. (C) 2004 Elsevier B.V All rights reserved.
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