Journal
SCIENCE
Volume 304, Issue 5678, Pages 1820-1822Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1096775
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Funding
- NCRR NIH HHS [RR10294] Funding Source: Medline
- NIMH NIH HHS [MH48850] Funding Source: Medline
- NINDS NIH HHS [NS29832] Funding Source: Medline
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PolyADP-ribose-polymerase 1 is activated in neurons that mediate several forms of long-term memory in Aplysia. Because polyADP-ribosylation of nuclear proteins is a response to DNA damage in virtually all eukaryotic cells, it is surprising that activation of the polymerase occurs during learning and is required for long-term memory. We suggest that fast and transient decondensation of chromatin structure by polyADP-ribosylation enables the transcription needed to form long-term memory without strand breaks in DNA.
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