Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 110, Issue 3, Pages 459-461Publisher
WILEY
DOI: 10.1002/ijc.11649
Keywords
human endogenous retrovirus K; germ cell tumor; antibodies to HERV-K Gag and Env
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Germ cell tumors (GCT) are strictly associated with the expression of HERV-K(HML-2) proviruses, and the majority of GCT patients produce antibodies to structural proteins of these proviruses. The objective of our study was to determine the significance of the serological response to HERV-K(HML-2) Gag and Env proteins for diagnosis, management of GCT patients and estimation of the therapy success. The data document a strong association of HERV-K(HML-2) antibodies and the clinical manifestation of the disease and therapy success. HERV-K(HML-2) antibodies seem to have an important diagnostic value as well as indicator of chemotherapy success. (C) 2004 Wiley-Liss, Inc.
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