Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 12, Pages 3131-3134Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.04.046
Keywords
cysteine proteases; active site-directed probe; isotopic labeling; suicide inhibitor; synthesis; chemical proteomics
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Funding
- NIGMS NIH HHS [GM 62502] Funding Source: Medline
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Quantification studies of complex protein mixtures have been restricted mainly to whole cell extracts. Here we describe the synthesis of two sets of isotope-coded activity-based probes that allow quantitative functional proteomics experiments on the cathepsins. (C) 2004 Elsevier Ltd. All rights reserved.
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