Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 14, Issue 12, Pages 3109-3112Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.04.023
Keywords
hACAT-1 and hACAT-2; inhibitor; lignans; S. chinensis; hypocholesterolemic activity
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The sesquineolignan, saucerneol B (1), and dineolignans, manassantin A (2), and manassantin B (3), were isolated from the methanol extracts of Saururus chinensis root and elucidated by their spectroscopic data analysis. Compounds 1-3 inhibited hACAT-1 and hACAT-2 with IC50 values of 43.0 and 124.0 muM for 1, of 39.0 and 8.0 muM for 2, of 82.0 muM and only 32% inhibition at 1 mM for 3, respectively. The EtOAc-soluble fraction, which contained compounds 1-3, of methanol extracts of S. chinensis exhibited strong cholesterol-lowering effect in high cholesterol-fed mice. (C) 2004 Elsevier Ltd. All rights reserved.
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