Journal
LANGMUIR
Volume 20, Issue 13, Pages 5153-5156Publisher
AMER CHEMICAL SOC
DOI: 10.1021/la049298n
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A method of fabricating photo-cross-linked hydrogels with gradients of immobilized molecules and cross-linking densities is introduced. Two macromer/initiator solutions are injected into a unique poly(dimethylsiloxane) channel system that produces a prepolymer gradient that is subsequently polymerized into a water-swollen hydrogel with ultraviolet light exposure. The gradient is controlled by the injection flow rate (optimized to 0.3 muL/min per inlet to produce a linear gradient). The technique is investigated both through fabrication of adhesive ligand gradients that modulate spatial distribution of attached endothelial cells and gradients of cross-linking densities that led to unique hydrogel architectures and spatially dependent swelling.
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