Journal
TETRAHEDRON LETTERS
Volume 45, Issue 27, Pages 5287-5290Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2004.05.008
Keywords
building blocks; tricyclic lactams; gamma-Keto-acid
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In order to mimic the complexity of natural products, we designed and obtained with simple synthetic methods, building blocks with 'quaternary chiral centers'. These tricyclic lactams resulted from the reaction of a functional gamma-keto-acid and various commercially available bi-nucleophiles. (C) 2004 Elsevier Ltd. All rights reserved.
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