Journal
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
Volume 11, Issue 4, Pages 375-381Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.GME.0000113848.74835.1A
Keywords
hot flashes; breast cancer; core temperature; energy expenditure; respiratory quotient; metabolism
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Funding
- NCRR NIH HHS [RR 00095] Funding Source: Medline
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Objective: To examine core body temperature, energy expenditure, and respiratory quotient among breast cancer survivors experiencing hot flashes and compare these data to published studies from healthy women. Design: In an observational study, nine breast cancer survivors with daily hot flashes who met specified criteria spent 24 hours in a temperature- and humidity-controlled whole-room indirect calorimeter (ie, metabolic room). Demographic and disease/treatment information were obtained and the following were measured: hot flashes via sternal skin conductance monitoring (sampled every second); core body temperature via an ingested radiotelemetry pill (sampled every 10 seconds); and energy expenditure and respiratory quotient via a whole-room indirect calorimeter (calculated every minute). Results: Circadian analysis of core temperature indicated wide variability with disrupted circadian rhythm noted in all women. Core temperature began to rise 20 minutes pre-flash to 7 minutes pre-flash (0.09degreesC increase). Increases in energy expenditure and respiratory quotient increased with each hot flash. Conclusions: Findings are comparable to published data from healthy women and warrant replication in larger, more diverse samples of women treated for breast cancer.
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