Journal
JOURNAL OF IMMUNOLOGY
Volume 173, Issue 1, Pages 15-19Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.1.15
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Funding
- NIAID NIH HHS [R01 AI014782] Funding Source: Medline
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Accumulating evidence indicates that positive selection events mediate differentiation, lineage commitment, and longevity of B lymphocytes. The BCR plays a central role, dictating the likelihood that newly formed cells will complete maturation, as well as whether cells persist within mature pools. Competition among B cells for limited, life span-promoting resources, which include self-ligands, lineage-specific cytokines, and innate receptor ligands, underlie these selective processes. Together, these observations suggest that positive selection is a critical feature in the establishment and maintenance of all lymphocyte pools, prompting re-evaluation of the underlying biological rationale for this process.
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