Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 5, Issue 7, Pages 531-541Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1427
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We are only starting to understand the molecular mechanisms that underlie cell and tissue movements during morphogenesis in metazoans. Dictyostelium discoideum provides a valuable model system for understanding these events-as it has for chemotaxis-despite the many differences that exist between this social amoeba and more complex organisms. Genetic and genomic studies, combined with real-time imaging, have identified key pathways that regulate morphogenesis in D. discoideum, and which are likely to have similar roles in metazoans.
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