Journal
ALCOHOL
Volume 33, Issue 3, Pages 175-181Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.alcohol.2004.06.007
Keywords
alcohol; T cells; T-cell-APC interactions
Categories
Funding
- NIAAA NIH HHS [AA-09598, AA-14405] Funding Source: Medline
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Chronic excessive consumption of ethanol causes immunodeficiency in human beings and in mice. Immunologic changes have been described in both species, including T-cell and innate immune system cell activation, among others. The features of chronic ethanol-induced activation have similarities in the two species, including an increased effector subset in both CD4(+) and CD8(+) T cells. There are also features of activation observed in the splenic macrophages of mice consuming ethanol chronically, including increased up-regulation of CD80 and CD86. Because these molecules are involved in T-cell-antigen-presenting cell interactions in vivo, it is of interest to ask whether these and other pathways of interaction are important in the T-cell activation and cytokine skewing described in chronic ethanol abuse. Preliminary findings from comparisons of wild-type, CD40 ligand knock-out, and CD28 knock-out C57BL/6 mice strongly support the suggestion of a critical role for T-cell-antigen-presenting cell interactions in the immune alterations observed in chronic ethanol abuse. (C) 2004 Elsevier Inc. All rights reserved.
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