Journal
HUMAN IMMUNOLOGY
Volume 65, Issue 7, Pages 676-682Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2004.04.006
Keywords
macrophages; apoptosis; inflammation
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These studies characterize a molecule known as regeneration and tolerance factor (RTF), which controls inflammation by regulating interleukin 1beta (IL-1beta) secretion. Recently, it has been demonstrated that the interaction of adenosine triphosphate (ATP) with the P2X7 purinoceptor induces the secretion of IL-1beta and initiates the inflammatory response. In these experiments, that the addition of ATP to macrophages was found to induce P2X7 activation and secretion of IL-1beta. This secretion is enhanced with anti-RTF antibody in combination with exogenous ATP (p< 0.005). RTF is also revealed to be able to influence surface ATPase activity and, increase PI incorporation, which is an indicator of P2X7 activation. We demonstrate that RTF has a role in controlling IL-1beta secretion by regulating P2X7 activity.
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