Journal
DIABETES CARE
Volume 27, Issue 7, Pages 1554-1558Publisher
AMER DIABETES ASSOC
DOI: 10.2337/diacare.27.7.1554
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Funding
- NCRR NIH HHS [RR06022] Funding Source: Medline
- NICHD NIH HHS [HD37251] Funding Source: Medline
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OBJECTIVE - The efficacy of the insulin analogs now available for Multiple daily injection (MDI) and continuous subcutaneous insulin infusion (CSII) therapy in type 1 diabetes has not yet been established in pediatric patients. Our principal aim in this short-term study was to compare the efficacy of CSII to MDI With glargine in lowering HbA, levels in children and adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS - Thirty-two youth with type 1 diabetes (age 8-21 years) were randomly assigned to receive either MDI treatment with once-daily glargine and premeal/snack insulin aspart or CSII with insulin aspart. Dose titration in both groups was based on home self-monitored blood glucose measurements and monthly HbA(1c). HbA(1c), total daily insulin dose (TDD), self-monitored blood glucose readings, and adverse events were compared after 16 weeks of therapy. RESULTS - while there was no significant change in the glargine group (HbA(1c) 8.2% at baseline vs. 8.1% at 16 weeks), youth randomized to CSII had a sharp reduction in HbA(1c) levels, from 8.1 to 7.2% after 16 weeks of therapy (P < 0.02 vs. baseline and <0.05 vs. glargine group). TDD was unchanged in the glargine group, but significantly dropped with CSII (1.4 units/kg at baseline vs. 0.9 units/kg at 16 weeks, P < 0.01). Both groups had similar basal doses and insulin-to-carbohydrate ratios. Fasting self-monitored blood glucose was similar in both groups, but lunch, dinner, and bedtime readings were significantly lower in the CSTI group (P < 0.01). CONCLUSIONS - Lower HbA, and premeal glucose levels were more achievable in this short-term Study with CSII than with glargine-based MD1 treatment. CSII is an efficacious treatment to improve metabolic control in youth with type 1 diabetes.
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