Journal
AMERICAN JOURNAL OF SURGERY
Volume 188, Issue 1A, Pages 36S-41SPublisher
EXCERPTA MEDICA INC
DOI: 10.1016/S0002-9610(03)00295-2
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Wet treatment of wounds has been used as an irrigation method since the seventh century. We have developed the concept of an in vivo tissue culture that facilitates wound healing and allows tissue engineering. A transparent, flexible, round chamber provides the wet environment. This system heals clean wounds as fast or faster than any other method, with less scarring. It allows delivery of analgesics, antibiotics, growth factors, growth media, and cells into the chamber, becoming a platform for tissue engineering. Gene therapy of the wound can be done in the chamber with growth factor and other genes. A tetracycline switch allows precise timing and amounts of expression and provides the opportunity for sequential expression of genes delivered at the same time. (C) 2004 Excerpta Medica, Inc. All rights reserved.
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