Journal
APPLIED SURFACE SCIENCE
Volume 307, Issue -, Pages 224-233Publisher
ELSEVIER
DOI: 10.1016/j.apsusc.2014.04.018
Keywords
magnetic nanoparticles; Folic acid; Hyperthermia
Categories
Funding
- National Natural Science Foundation of China (NSFC) [21246002]
- National Basic Research Program of China (973 Program) [2009CB219904]
- National Post-doctoral Science Foundation [20090451176]
- Jiangsu Provincial Key Lab. of Environmental Materials and Engineering at the Yangzhou University [1K11025]
- Technology Innovation Foundation of MOST [11C26223204581]
- Natural Science Foundation of Jiangsu Prov [B1K2011328]
- Minjiang Scholarship of Fujian Prov (Fujian Higher Education [117]
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The folic acid (FA)-conjugated Fe304 magnetic nanoparticles (MNPs) were synthesized by coprecipitation of Fe3-1 and Fe2+ solution followed by surface modification with carboxymethyl dextran (CMD) to form carboxymethyl group terminated MNPs, then FA was conjugated with the carboxyl group functionalized MNPs. The morphology and properties of obtained nanoparticles were characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), UV-visible spectra (UV-vis), transmission electron microscopy (TEM), dynamic light scattering (DLS), vibrating sample magnetometer (VSM) and thermogravimetric analysis (TGA). The FA-conjugated MNPs exhibited relatively high saturation magnetization and fast magneto-temperature response which could be applied to hyperthermia therapy. To determine the accurate targeting effect of FA, we chose FA-conjugated MNPs as MRI contrast enhancement agent for detection of KB cells with folate receptor over-expression in vitro and in vivo. The results show that these magnetic nanoparticles appear to be the promising materials for local hyperthermia and MRI. C) 2014 Published by Elsevier B.V.
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