Journal
BIOCHEMICAL JOURNAL
Volume 381, Issue -, Pages 19-23Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BJ20040566
Keywords
ATP synthase; cytochrome c; Mgm1p; mitochondria; rhomboid-like protease; Tim11p
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Funding
- NIGMS NIH HHS [R01 GM057067, GM57067] Funding Source: Medline
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In Saccharomyces cerevisiae, two mitochondrial inner-membrane proteins play critical roles in organellar morphology. One is a dynamin-related GTPase, Mgm1p, which participates in mitochondrial fusion. Another is Tim11p, which is required for oligomeric assembly of F1Fo-ATP synthase, which generates ATP through oxidative phosphorylation. Our data bring these findings together and define a novel role for Mgm1p in the formation and maintenance of mitochondrial cristae. We show that Mgm1p serves as an upstream regulator of Tim11p protein stability, ATP synthase assembly, cristae morphology and cytochrome c storage within cristae.
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