Synthesis of protected (purin-6-yl)glycines via Pd-catalyzed α-arylation of ethyl N-(diphenylmethylidene)glycinate with 6-iodopurines

A synthesis of protected (purin-6-yl)glycines, potential building blocks of stable covalent peptide-nucleic acids conjugates, was achieved via Pd-catalyzed alpha-arylation of ethyl N-(diphenylmethylidene)glycinate with 6-iodopurine.