Journal
EUROPEAN POLYMER JOURNAL
Volume 40, Issue 7, Pages 1355-1361Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2004.02.015
Keywords
chitosan; quaternized chitosan; synthesis; antibacterial activity
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Chitosan with excellent biodegradable and biocompatible characteristics has received attention as an oral drug delivery vehicle. A quaternized chitosan (i.e., N-diethylmethyl chitosan, DEMC) was prepared based on a modified two-step process via a 2(2) factorial design to optimize the preparative conditions. DEMC was fully characterized using FTIR and H-1-NMR spectroscopies. As calculated using NMR-based data, high degree of quaternization was achieved through the optimized two-step process. The highly quaternized biopolymeric derivative was subjected to microbial experiments. The antimicrobial activities of chitosan and DEMC against Escherchia coli were compared by calculation of minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Our data indicates that although the antimicrobial activity of DEMC is higher than that of chitosan in acetic acid medium, the both compounds are pH dependent and an increase in concentration of acetic acid results in a significant decrease in both MIC and MBC. (C) 2004 Elsevier Ltd. All rights reserved.
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