Journal
JOURNAL OF PSYCHIATRIC RESEARCH
Volume 38, Issue 4, Pages 413-416Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2004.01.003
Keywords
serum homocysteine; schizophrenia; MTHFR; neurotoxicity
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We previously found a marked elevation of plasma homocysteine in young male schizophrenic patients in hospital. It seemed important to determine if this finding is already present in newly admitted schizophrenic patients. Serum homocysteine levels were studied in 184 consecutively admitted schizophrenic patients and 305 control subjects from an employee screening program. Homocysteine levels were markedly increased in this population of newly admitted schizophrenic patients, especially in young males. Newly admitted male schizophrenic patients have elevated homocysteine levels that cannot be explained on the basis of poor hospital nutrition. Smoking may raise homocysteine by 1-2 muM/L but this is not a large enough effect to explain our findings. (C) 2004 Elsevier Ltd. All rights reserved.
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