Journal
ANNALS OF SURGICAL ONCOLOGY
Volume 11, Issue 7, Pages 665-673Publisher
SPRINGER
DOI: 10.1245/ASO.2004.10.026
Keywords
chemoradiation; chemotherapy; esophageal cancer; neoadjuvant therapy; surgery
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Most patients with esophageal cancer present with locoregional disease, and the optimal initial management is controversial. The current National Comprehensive Cancer Network (NCCN) practice guidelines support diverse treatment options for locoregional disease, including surgical resection alone, definitive chemoradiation therapy, and preoperative combined-modality (neoadjuvant/trimodality) therapy. Many cancer centers worldwide favor a neoadjuvant approach, although the evidence supporting this practice is inconsistent. A concise review of the literature is presented. The topics discussed do not necessarily reflect each author's opinions or clinical practices.
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