Journal
PHARMACEUTICAL STATISTICS
Volume 3, Issue 3, Pages 213-215Publisher
WILEY
DOI: 10.1002/pst.125
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A sample size justification should be given for all clinical investigations. However, sometimes the objective of a trial is to estimate an effect with a view to planning a later definitive study. This paper describes the calculations for designing studies where one wishes to adopt an estimation approach through using confidence intervals around the overall response. Calculations are given for data anticipated to take a Normal form. Copyright (C) 2004 John Wiley Sons Ltd.
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