Journal
NATURE NEUROSCIENCE
Volume 7, Issue 7, Pages 697-698Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1262
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Funding
- NIDA NIH HHS [R01 DA14725] Funding Source: Medline
- NINDS NIH HHS [R01 NS30219] Funding Source: Medline
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In hippocampal pyramidal cells, a rise in Ca2+ releases endocannabinoids that activate the presynaptic cannabinoid receptor (CB1R) and transiently reduce GABAergic transmission-a process called depolarization-induced suppression of inhibition (DSI). The mechanism that limits the duration of endocannabinoid action in intact cells is unknown. Here we show that inhibition of cyclooxygenase-2 (COX-2), not fatty acid amide hydrolase (FAAH), prolongs DSI, suggesting that COX-2 limits endocannabinoid action.
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