Journal
GENES & DEVELOPMENT
Volume 18, Issue 13, Pages 1513-1526Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1206204
Keywords
U2AF; RNA recognition motif; protein-protein interaction; RNA-binding domain; PUMP; splicing factor
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Funding
- NIAID NIH HHS [P30 AI42855, P30 AI042855] Funding Source: Medline
- NIGMS NIH HHS [R01 GM070503, R01 GM070503-01] Funding Source: Medline
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Recent structures of the heterodimeric splicing factor U2 snRNP auxiliary factor (U2AF) have revealed two unexpected examples of RNA recognition motif (RRM)-like domains with specialized features for protein recognition. These unusual RRMs, called U2AF homology motifs (UHMs), represent a novel class of protein recognition motifs. Defining a set of rules to distinguish traditional RRMs from UHMs is key to identifying novel UHM family members. Here we review the critical sequence features necessary to mediate protein-UHM interactions, and perform comprehensive database searches to identify new members of the UHM family. The resulting implications for the functional and evolutionary relationships among candidate UHM family members are discussed.
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