Journal
APPLIED SURFACE SCIENCE
Volume 302, Issue -, Pages 262-267Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2013.09.081
Keywords
MAPLE; Microspheres thin coatings; PLA-PVA; Usnic acid; Anti-biofilm; Staphylococcus aureus
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We report the fabrication of thin coatings of PLA-PVA microspheres loaded with usnic acid by matrix assisted pulsed laser evaporation (MAPLE) onto Ti substrate. The obtained coatings have been physicochemically characterized by scanning electron microscopy (SEM) and infrared microscopy (IRM). In vitro biological assays have been performed in order to evaluate the influence of fabricated microsphere thin coatings on the Staphylococcus aureus biofilm development as well as their biocompatibility. SEM micrographs have revealed a uniform morphology of thin coatings, while IRM investigations have proved both the homogeneity and functional groups integrity of prepared thin coatings. The obtained microsphere-based thin coatings have proved to be efficient vehicles for usnic acid natural compound with antibiofilm activity, as demonstrated by the inhibitory activity on S. aureus mature biofilm development, opening new perspectives for the prevention and therapy associated to biofilm related infections. (C) 2013 Elsevier B.V. All rights reserved.
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