Journal
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
Volume 10, Issue 4, Pages 639-643Publisher
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S1355617704104050
Keywords
hippocampus; memory; consolidation; Alzheimer's disease
Categories
Funding
- NIA NIH HHS [1P01 AG12435, P01 AG012435, P50 AG023501, P01 AG019724, R01 AG010897, U01 AG024904] Funding Source: Medline
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This study tested the hypothesis that the hippocampus has a relatively specific role in retaining information over delays. Thirty-seven subjects with probable Alzheimer's disease were evaluated with a verbal memory task and structural MRI. Cortical gray matter but not hippocampal volume predicted immediate free recall. In contrast, hippocampal volume was the best predictor of how well information was retained over a delay, even after controlling for levels of immediate recall. Results suggest that the role of the hippocampus is relatively specific to the consolidation of new memories.
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