Journal
JOURNAL OF VASCULAR SURGERY
Volume 40, Issue 1, Pages 187-193Publisher
MOSBY-ELSEVIER
DOI: 10.1016/j.jvs.2004.03.043
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Funding
- NHLBI NIH HHS [U01 HL066949, R01 HL057854] Funding Source: Medline
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Nitric oxide (NO) is a molecule that has gained recognition as a crucial modulator of vascular disease. NO has a number of intracellular effects that lead to vasorelaxation, endothelial regeneration, inhibition of leukocyte chemotaxis, and platelet adhesion. Its role in vascular disease has been intensively investigated and further elucidated over the past two decades. It is important in the pathogenesis of many cardiovascular diseases, including atherosclerosis, intimal hyperplasia, and aneurysmal disease. In addition, NO has been used as a therapeutic tool to treat diseases that range from recurrent stenosis to inhibiting thrombotic events. Many commonly used medications have their therapeutic actions through the production of NO. This review highlights the vascular biologic characteristics of NO, its role in the pathogenesis of cardiovascular disease processes, and its potential therapeutic applications.
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