Journal
INFECTION AND IMMUNITY
Volume 72, Issue 7, Pages 4290-4292Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.72.7.4290-4292.2004
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Funding
- NIAID NIH HHS [K08 AI051526, K08 AI 51526-01] Funding Source: Medline
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Intranasal challenge of C57BL/6 mice with Streptococcus pneumoniae serotypes 6B, 14, and 23F produced colonization of the middle ear and NP. Intranasal vaccination with ethanol-killed nonencapsulated cells with adjuvant protected both sites. Of four nontoxic adjuvants tested, the cholera toxin B subunit was most effective and least nonspecifically protective.
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