Journal
CLINICAL NEUROPHARMACOLOGY
Volume 27, Issue 4, Pages 195-197Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.wnf.0000134409.97397.5e
Keywords
cyclosporine A toxicity; ocular opsoclonus; reversible posterior leukoencephalopathy; liver transplantation
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Ocular opsoclonus is a rare neurologic condition that occurs in patients with brain stem encephalitis, neoplasm of the mesencephalon, paraneoplastic syndrome or intoxication. Neurotoxicity is a well-known complication of cyclosporine-A (CSA) therapy. We report a case of a 17-year-old patient, a Caucasian female, who underwent an orthotopic liver transplantation (OLT) for immunologic cirrhosis and chronic cellular rejection respectively. The ocular symptoms occurred 8 days after the OLT. She also developed reversible posterior leukoencephalopathy. The serum level of CSA was 412ng/mL. The ocular symptoms improved 21 days after the reduction of the CSA level.
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