Journal
BIOSTATISTICS
Volume 5, Issue 3, Pages 445-464Publisher
OXFORD UNIV PRESS
DOI: 10.1093/biostatistics/kxh001
Keywords
complete case analysis; ignorability; last observation carried forward; missing at random; missing completely at random; missing not at random
Funding
- NCI NIH HHS [CA-57030] Funding Source: Medline
- NIEHS NIH HHS [P30-ES09106] Funding Source: Medline
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Using standard missing data taxonomy, due to Rubin and co-workers, and simple algebraic derivations, it is argued that some simple but commonly used methods to handle incomplete longitudinal clinical trial data, such as complete case analyses and methods based on last observation carried forward, require restrictive assumptions and stand on a weaker theoretical foundation than likelihood-based methods developed under the missing at random (MAR) framework. Given the availability of flexible software for analyzing longitudinal sequences of unequal length, implementation of likelihood-based MAR analyses is not limited by computational considerations. While such analyses are valid under the comparatively weak assumption of MAR, the possibility of data missing not at random (MNAR) is difficult to rule out. It is argued, however, that MNAR analyses are, themselves, surrounded with problems and therefore, rather than ignoring MNAR analyses altogether or blindly shifting to them, their optimal place is within sensitivity analysis. The concepts developed here are illustrated using data from three clinical trials, where it is shown that the analysis method may have an impact on the conclusions of the study.
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