Journal
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
Volume 118, Issue 1-3, Pages 253-267Publisher
SPRINGER
DOI: 10.1385/ABAB:118:1-3:253
Keywords
mycobacterium; lipoglycan; lipoarabinomannan; structure; capillary electrophoresis; nuclear magnetic resonance
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Mycobacterium tuberculosis, the causative agent of tuberculoses, is one of the most effective human pathogens. The mycobacterial cell envelope contains lipoglycans, and of particular interest is lipoarabinomannan (LAM), one of the most potent mycobacterial immunomodulatory molecules. The importance of lipoarabinomannan (LAM) in the immunopathogenesis of tuberculosis has incited structural studies on this molecule to (1) establish a precise structural model of the molecule and (2) decipher the structure/function relationships. In recent years, we have focused on the two domains essential for LAM biologic activities: the mannosyl-phosphatidyl-nlyo-inositol anchor and the caps. We review here the recent procedures developed for the structural analysis of these domains.
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