Journal
NATURE MEDICINE
Volume 10, Issue 7, Pages S34-S41Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn1433
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The combination of an aging population and the promise, possibly in the near future, of disease-modifying therapies have made the characterization of the early stages of Alzheimer's disease (AD) a topic of major research interest. In this article we review recent progress in our understanding of the evolution of early AD with particular reference to the symptomatic pre-dementia stage designated 'mild cognitive impairment', emphasizing work on the early cognitive profile and associated neuroimaging studies.
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