Journal
JOURNAL OF FLUORESCENCE
Volume 14, Issue 4, Pages 377-389Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1023/B:JOFL.0000031819.45448.dc
Keywords
gold and silver nanoparticles; surface plasmon resonance; self assembled monolayer; protein-ligand binding; biosensor
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In this review article, we discuss a class of biosensors that exploit the change in the colorimetric properties of noble metal nanoparticles in response to biomolecular binding at their surface. Several sensor fabrication techniques as well as sensor configurations are discussed with an emphasis on their strengths and limitations. We conclude by presenting the future prospects and challenges for the successful transition of this technology from the laboratory to a commercial product.
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