Journal
VETERINARY PATHOLOGY
Volume 41, Issue 4, Pages 446-449Publisher
SAGE PUBLICATIONS INC
DOI: 10.1354/vp.41-4-446
Keywords
adrenal cortex neoplasms; ferrets; luteinizing hormone receptors; Mustelidae; ovariectomy; orchiectomy; transcription factor
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Funding
- NHLBI NIH HHS [HL61006] Funding Source: Medline
- PHS HHS [P30 D52574] Funding Source: Medline
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Adrenocortical neoplasms are a common cause of morbidity in neutered ferrets. Recently we showed that gonadectomized DBA/2J mice develop adrenocortical tumors that express transcription factor GATA-4. Therefore, we screened archival specimens of adrenocortical neoplasms from neutered ferrets to determine whether GATA-4 could be used as a tumor marker in this species. Nuclear immunoreactivity for GATA-4 was evident in 19/22 (86%) of ferret adrenocortical carcinomas and was prominent in areas exhibiting myxoid differentiation. Normal adrenocortical cells lacked GATA-4 expression. Two other markers of adrenocortical tumors in gonadectomized mice, inhibin-a and luteinizing hormone receptor, were coexpressed with GATA-4 in some of the ferret tumors. No GATA-4 expression was observed in three cases of nodular hyperplasia, but patches of anaplastic cells expressing GATA-4 were evident in 7/14 (50%) of tumors classified as adenomas. We conclude that GATA-4 can function as a marker of anaplasia in ferret adrenocortical tumors.
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