Journal
MOLECULAR IMMUNOLOGY
Volume 41, Issue 6-7, Pages 657-673Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2004.04.013
Keywords
TRPM ion channels; ADP-ribose; oxidative stress; CD38; NAD-glycohydrolases; NUDIX hydrolases; CAN channels; DT40 B-cells; Mg2+-homeostasis; cEF alpha kinase family
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Funding
- NIAID NIH HHS [5 T32 AI07405] Funding Source: Medline
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In just a few years, the discovery and subsequent characterization of several members of the TRPM family of cation channels have provided us with surprising new insights into unknown aspects of cellular ion-homeostasis regulation. This includes reports about ADP-ribose functioning as a novel intracellular second messenger and gating molecule of the Ca2+-permeable TRPM2 channel, studies demonstrating the central role of mouse TRPM5 in taste signaling, as well as the unexpected involvement of TRPM6 and TRPM7 in regulating Mg2+-homeostasis, or the cool properties of TRPM8 acting as a cold and menthol sensor in sensory neurons. At least four of the eight known TRPM proteins have been shown to be present in the immune context: TRPM1 (melastatin), TRPM2, TRPM4 and TRPM7. Although we currently lack animal models allowing a detailed assessment of the potential involvement of TRPM family members in modulating the immune response, the powerful combination of molecular and cellular biology, biochemistry, and electrophysiology have provided the first clues as to how these molecules could contribute to immunity. (C) 2004 Elsevier Ltd. All rights reserved.
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