Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 52, Issue 1, Pages 80-88Publisher
WILEY
DOI: 10.1002/mrm.20103
Keywords
spectroscopic imaging; k-space; contamination; resolution; prostate cancer
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The clinical application of 3D proton spectroscopic imaging (3D SI) of the human prostate requires a robust suppression of periprostatic lipid signal contamination, minimal intervoxel signal contamination, and the shortest possible measurement time. In this work, a weighted elliptical sampling of k-space, combined with k-space filtering and pulse repetition time (TR) reduction minimized lipid signals, intervoxel contamination, and measurement time. At 1.5 T, the MR-visible prostate metabolites citrate, creatine, and choline can now be mapped over the entire human prostate with uncontaminated spherical voxels, with a volume down to 0.37 cm(3), in measurement times of 7-15 min. (C) 2004 Wiley-Liss, Inc.
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