Journal
JOURNAL OF BONE AND MINERAL RESEARCH
Volume 19, Issue 7, Pages 1144-1153Publisher
WILEY
DOI: 10.1359/JBMR.040302
Keywords
osteoclast; chloride channel; osteoporosis; autosomal dominant osteopetrosis II; acidification; bone
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Chloride channel activity is essential for osteoclast function. Consequently, inhibition of the osteoclastic chloride channel should prevent bone resorption. Accordingly, we tested a chloride channel inhibitor on bone turnover and found that it inhibits bone resorption without affecting bone formation. This study indicates that chloride channel inhibitors are highly promising for treatment of osteoporosis.
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