Journal
MOLECULAR IMMUNOLOGY
Volume 41, Issue 6-7, Pages 675-686Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2004.01.007
Keywords
PKC theta; TCR; CD28; costimulation; T cell; lipid rafts; immunological synapse
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Funding
- NCI NIH HHS [CA35299] Funding Source: Medline
- NIAID NIH HHS [AI49888, 1 F32 AI51909-01] Funding Source: Medline
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Upon stimulation by environmental signals, T lymphocytes develop an intricate set of signal-dependent responses including remodeling of the actin cytoskeleton, the development of cellular polarity, the initiation of second-messenger cascades, entry into cell cycle, differentiation and effector function. The integration of TCR and costimulatory signaling is critical to the successful initiation of the T cell activation program, and the serine/threonine kinase PKCtheta is an important site of signal integration in the process of T cell activation. We provide an overview of T cell signaling, and then go on to assess our understanding of the regulation of PKCtheta activity, its target proteins and its role in T cell activation and the production of T cell survival factors such as IL-2. (C) 2004 Elsevier Ltd. All rights reserved.
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