Journal
AMERICAN JOURNAL OF KIDNEY DISEASES
Volume 44, Issue 1, Pages -Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1053/j.ajkd.2004.03.037
Keywords
hyperaldosteronism; hypocitraturia; kidney stone
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Funding
- NCRR NIH HHS [M01-RR00633] Funding Source: Medline
- NIDDK NIH HHS [R01-DK48482, P01-DK20543, T32 DK07257-23] Funding Source: Medline
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Typical manifestations of hyperaidosteronism Include salt retention, hypokalemia, and metabolic alkalosis. However, a consequence Infrequently recognized and described Is hypocitraturia. In combination with hypercalciuria, aldosterone-induced hypocitraturia can trigger calcium nephrolithiasis. The authors report a case of an Individual with primary hyperaidosteronism from an adrenal adenoma that resulted in hypocitraturia. The patient had severe recurrent renal calcium calculi that corrected with adrenalectomy. The clinical physiology of renal calcium and citrate handling In hyperaidosteronism is reviewed.
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