Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 190, Issue 1, Pages 123-126Publisher
UNIV CHICAGO PRESS
DOI: 10.1086/421472
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Funding
- NHLBI NIH HHS [R01 HL064550, R01 HL068533, HL64550, HL68533] Funding Source: Medline
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Region of difference (RD1) genes are present in virulent Mycobacterium tuberculosis but not the vaccine strain M. bovis bacille Calmette-Guerin (BCG). The deletion of RD1 from M. tuberculosis produces an attenuation strikingly like that of BCG, which suggests the use of RD1 mutant strains for improvement of the tuberculosis (TB) vaccine. We performed long-term murine infection with M. tuberculosis H37Rv:DeltaRD1 and BCG. Mice infected with H37Rv:DeltaRD1 gained less weight than did BCG-infected control mice, and, after >1 year, their lungs harbored many more bacteria and displayed significant levels of inflammation. This difference in virulence has important implications for the pursuit of strains lacking RD1 in the development of the TB vaccine.
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