Journal
HAEMOPHILIA
Volume 10, Issue 4, Pages 401-404Publisher
WILEY
DOI: 10.1111/j.1365-2516.2004.00922.x
Keywords
haemophilia B; inhibitor; immune tolerance; recombinant FIX
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We describe successful induction of immune tolerance in a 12-month-old patient with severe haemophilia B and low-titre and low response antifactor IX inhibitor at 5 Bethesda Unit (BU). Immune tolerance induction (ITI) was started with recombinant factor (rFIX) at 40-50 U kg(-1) day(-1) (1000 U three times per week) and 2 years after the beginning of therapy the inhibitor had been reduced to undetectable values. As complications, which appeared during the ITI, the patient presented minor haemorrhagic complications, which remitted following the administration of rFVIIa, and recurring infections of the catheter, requiring the withdrawal and subsequent placement of a new catheter.
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