Journal
APPLIED SURFACE SCIENCE
Volume 262, Issue -, Pages 28-33Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2012.01.010
Keywords
Alginate; Carboxymethyl cellulose; Ionic crosslinked beads; Controlled release; Oral protein delivery; Tissue engineering
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Funding
- Nuclear Research Development Program of the Korea Science and Engineering Foundation (KOSEF)
- Ministry of Education, Science and Technology (MEST, Korea) [2011-0002361, 2011-0020757]
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We developed Fe3+-crosslinked alginate-carboxymethyl cellulose (AC) beads in various volume ratios by dropping an AC solution into a ferric chloride solution to form protein therapeutic carrier beads. Scanning electron microscopy revealed that the roughness and pore size of the crosslinked beads increased with the volume ratio of the carboxymethyl cellulose. Fourier transform-infrared analysis revealed the formation of a three-dimensional bonding structure between the anionic polymeric chains of AC and the Fe3+ ions. The degree of swelling and the release profile of albumin from the beads were investigated under simulated gastrointestinal conditions (pH 1.2, 4.5, and 7.4). The Fe3+-crosslinked AC beads displayed different degrees of swelling and albumin release for the various AC volume ratios and under various pH conditions. An in vitro release test was used to monitor the controlled release of albumin from the AC beads under simulated gastrointestinal conditions over 24 h. The Fe3+-crosslinked AC beads protected and controlled the release of protein, demonstrating that such beads present a promising protein therapeutic carrier for the oral delivery. Crown Copyright (c) 2012 Published by Elsevier B.V. All rights reserved.
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