Journal
JOURNAL OF IMMUNOLOGY
Volume 173, Issue 1, Pages 402-409Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.173.1.402
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Polymorphism within the MHC not only affects peptide specificity but also has a critical influence on the T cell repertoire; for example, the CD8 T cell response toward an inummodominant HSV glycoprotein B peptide is more diverse and of higher avidity in H-2(bm8) compared with H-2(b) mice. We have examined the basis for the selection of these distinct antiviral T cell repertoires by comparing the high-resolution structures of K-b and k(bm8), in complex with cognate peptide Ag. Although K-b and k(bm8) differ by four residues within the Ag-binding cleft, the most striking difference in the two structures was the disparate conformation adopted by the shared residue, Arg(62). The altered dynamics of Arg62, coupled with a small rigid-body movement in the a, helix encompassing this residue, correlated with biased Valpha usage in the B6 mice. Moreover, an analysis of all known TCR/MHC complexes reveals that Arg(62) invariably interacts with the TCR CDR1alpha loop. Accordingly, Arg(62) appears to function as a conformational switch that may govern T cell selection and protective immunity.
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